| Language | Comment |
| C | Base API (included in distribution) |
| C++ | Object-oriented wrapper for the C API |
| CommonLisp | MaiSQL for CMUCL |
| Delphi | Direct MySQL interface (not using ODBC) |
| Dylan | Dynamic object-oriented language |
| Eiffel | Another object-oriented language |
| Guile | The GNU extension language |
| Java | Two maintained type 4 JDBC drivers |
| ODBC | MyODBC is a type 2.5 driver. |
| PHP | Server-side, HTML-embedded scripting |
| - | language |
| Perl | DBI/DBD: database-independent Perl |
| - | interface |
| Pike | Language used in the Roxen web server |
| Python | Object-oriented scripting language |
| Ruby | Object-oriented scripting language from |
| - | Japan |
| TCL | Scripting language |
